Publications

All Publications from Medline

All Preprints in BioRxiv

Key Papers

Galeone A, Solazzo E, Lavezzari F, Han SY, Consonni G, My B, Rizzo R, Gigli G, Jafar-Nejad H, Vaccari T. (2026) TUSC3 serves as a rate-limiting gatekeeper of a glycan-mediated ER Triage Checkpoint for BMP4/Dpp. Cell Reports, in press (biorxiv version).

Totaro S, Lettieri A, Castiglioni S, Lavezzari F, Gervasini C, Massa V, Vaccari T. (2025). Tumor-suppressive activities of SA1/STAG2 and effects of PARP impairment during brain development. Disease Models and Mechanisms doi: 10.1242/dmm.052440

Frappaolo A, Karimpour-Ghahnavieh A, Cesare G, Sechi S, Fraschini R, Vaccari T, Giansanti MG (2022). GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila. Cell Death and Disease doi: 10.1038/s41419-022-05438-9.

Formica M, Storaci AM, Bertolini I, Carminati F, Knævelsrud H, Vaira V, Vaccari T (2021). V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis. Autophagy doi: 10.1080/15548627.2021.1918915.

Morelli E, Speranza E, Pellegrino E, Beznoussenko G, Carminati F, Garré M, Mironov AA, Onorati M and Vaccari T (2021). The SNARE protein SNAP29 is a new regulator of vesicle transport at the Golgi Apparatus and Endoplasmic Reticulum. Frontiers in Cell and Developmental Biology doi: 10.3389/fcell.2021.637565

Terrasi A, Bertolini I, Martelli C, Gaudioso G, Di Cristofori, Storaci AM, Formica M, Bosari S, Cairoli M, Ottobrini L, Vaccari T*, Vaira V (2019). A Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivoSpecific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo. EBioMedicine https://doi.org/10.1016/j.ebiom.2019.01.052

Mastrodonato V, Beznoussenko G, Mironov A, Ferrari L, Deflorian G & Vaccari T (2019). A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Scientific Reports  doi: 10.1038/s41598-018-37780-4

Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garrè M, Morelli E, Vaccari T, Poletti A. (2018). Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. Autophagy  doi: 10.1080/15548627.2018.1535292

Morelli E, Mastrodonato V, Beznoussenko G, Mironov AA, Tognon E, Vaccari T (2016). An essential step of kinetochore formation controlled by the SNARE protein Snap29. The EMBO Journal PDF-EMBOJ-2016

Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T (2016). Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB/V-ATPase axis in Drosophila melanogaster. Autophagy PDF-Aut-2016

Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten TE, Bilder D, Stenmark H, Mironov AA, Vaccari T (2014). Multiple functions of the SNARE protein Snap29 in autophagy, endocytic and exocytic trafficking during epithelial formation in Drosophila. Autophagy. PDF-Aut-2014

Kobia F, Duchi S, Deflorian G, Vaccari T (2014). Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling. Molecular Oncology PDF-Mol Oncol-2014

Tognon E, Wollscheid N, Cortese K, Tacchetti C, Vaccari T (2014). ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila. PLoS ONE  PDF-PlosONE-2014

Petzoldt AG, Gleixner EM, Fumagalli A, Vaccari T* and Simons M (2013). Activation of the proton pump, V-ATPase, triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Disease Models & Mechanisms  PDF-PlosONE-2014 *co-corresponding.

Vaccari T*, Duchi S, Cortese K, Tacchetti C, Bilder D (2010). The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development  PDF-Develop-2010 *co-corresponding

Key Reviews + Technicals

Smeele PH, Cesare G, Vaccari T. (2024) ALS’ Perfect Storm: C9orf72-Associated Toxic Dipeptide Repeats as Potential Multipotent Disruptors of Protein Homeostasis. Cells. doi: 10.3390/cells13020178.

Smeele PH, Vaccari T. (2022) Snapshots from within the cell: Novel trafficking and non trafficking functions of Snap29 during tissue morphogenesis. Semin Cell Dev Biol. doi: 10.1016/j.semcdb.2022.02.024.

Gualtieri M, Vaccari T. (2019) Genetic and Cell Biology Methods to Study ESCRTs in Drosophila melanogaster. Methods Mol Biol. doi: 10.1007/978-1-4939-9492-2_2.

Mastrodonato V, Morelli E, Vaccari T. (2018) How to use a multipurpose SNARE: The emerging role of Snap29 in cellular health. Cell Stress  doi: 10.15698/cst2018.04.130.

Alfred V, Vaccari T. (2018)  Mechanisms of Non-canonical Signaling in Health and Disease: Diversity to Take Therapy up a Notch? Adv Exp Med Biol doi: 10.1007/978-3-319-89512-3_9.

Horner D, Pasini ME, Beltrame M, Mastrodonato V, Morelli E,  Vaccari T. (2017). ESCRT genes in developmental signaling. Seminars in Cell & Developmental Biology  

Tognon E, Vaccari T. (2014). Immunohistochemical tools and techniques to visualize Notch in Drosophila melanogaster. Methods Mol Biol.  doi: 10.1007/978-1-4939-1139-4_5.

Rusten TE, Vaccari T, Stenmark H (2012). Shaping Development with ESCRTs. Nature Cell Biology. PDF-Nat Cell Biol-2012

Undergraduate courses thought by Thomas

1. Biologia Generale e Ambientale con elementi di Istologia. Corso di laurea triennale in Scienze Naturali. 2018- ongoing (Fall Semester).
2. Advanced Molecular and Cellular Biotechnology. Master of Science in Molecular Biotechnology and Bioinformatics – 2018- ongoing (Spring Semester)
3. Cell Population Dynamics. Master of Science in Quantitative Biology – 2022- ongoing (Spring Semester)

Graduate mentoring by Thomas

Thomas is part of the faculty of the Multiscale Integrative Biology PhD program of the University of Milan