All Publications from Medline

Key Papers

Pandey A, Galeone A, Han SY, Story BA, Consonni G, Mueller WF, Steinmetz LM, Vaccari T, Jafar-Nejad H. (2023). Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila.
Nature Communications doi: 10.1038/s41467-023-40910-w.

Frappaolo A, Karimpour-Ghahnavieh A, Cesare G, Sechi S, Fraschini R, Vaccari T, Giansanti MG (2022). GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila.
Cell Death and Disease doi: 10.1038/s41419-022-05438-9.

Fajner V, Giavazzi F, Sala S, Oldani A, Martini E, Napoletano F, Parazzoli D, Cesare G, Cerbino R, Maspero E, Vaccari T*, Polo S (2021). Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles. Nature Communications doi: 10.1038/s41467-021-25809-8

Formica M, Storaci AM, Bertolini I, Carminati F, Knævelsrud H, Vaira V, Vaccari T (2021). V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis.
Autophagy doi: 10.1080/15548627.2021.1918915.

Morelli E, Speranza E, Pellegrino E, Beznoussenko G, Carminati F, Garré M, Mironov AA, Onorati M and Vaccari T (2021). The SNARE protein SNAP29 is a new regulator of vesicle transport at the Golgi Apparatus and Endoplasmic Reticulum. Frontiers in Cell and Developmental Biology doi: 10.3389/fcell.2021.637565

Terrasi A, Bertolini I, Martelli C, Gaudioso G, Di Cristofori, Storaci AM, Formica M, Bosari S, Cairoli M, Ottobrini L, Vaccari T*, Vaira V (2019). A Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivoSpecific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo. EBioMedicine https://doi.org/10.1016/j.ebiom.2019.01.052

Mastrodonato V, Beznoussenko G, Mironov A, Ferrari L, Deflorian G & Vaccari T (2019). A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Scientific Reports  https://www.nature.com/articles/s41598-018-37780-4

Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garrè M, Morelli E, Vaccari T, Poletti A. (2018). Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. Autophagy 18:1-21. doi: 10.1080/15548627.2018.1535292

Morelli E, Mastrodonato V, Beznoussenko G, Mironov AA, Tognon E, Vaccari T (2016). An essential step of kinetochore formation controlled by the SNARE protein Snap29. The EMBO Journal 35(20): 2223-37. PDF-EMBOJ-2016

Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T (2016). Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB/V-ATPase axis in Drosophila melanogaster. Autophagy 12(3): 499-514. PDF-Aut-2016

Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten TE, Bilder D, Stenmark H, Mironov AA, Vaccari T (2014). Multiple functions of the SNARE protein Snap29 in autophagy, endocytic and exocytic trafficking during epithelial formation in Drosophila. Autophagy 10(12): 2251-68. PDF-Aut-2014

Kobia F, Duchi S, Deflorian G, Vaccari T (2014). Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling. Molecular Oncology pii: S1574-7891(13): 00160-9. PDF-Mol Oncol-2014

Tognon E, Wollscheid N, Cortese K, Tacchetti C, Vaccari T (2014). ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila. PLoS ONE 9(4): e93987. PDF-PlosONE-2014

Petzoldt AG, Gleixner EM, Fumagalli A, Vaccari T* and Simons M (2013). Activation of the proton pump, V-ATPase, triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Disease Models & Mechanisms 6(3): 689-700. PDF-PlosONE-2014 *co-corresponding.

Vaccari T*, Duchi S, Cortese K, Tacchetti C, Bilder D (2010). The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development 137 (11): 1825-32. PDF-Develop-2010 *co-corresponding

Key Reviews + Technicals

Smeele PH, Vaccari T. (2022) Snapshots from within the cell: Novel trafficking and non trafficking functions of Snap29 during tissue morphogenesis. Semin Cell Dev Biol. 2022 Mar 4:S1084-9521(22)00063-5. doi: 10.1016/j.semcdb.2022.02.024.

Gualtieri M, Vaccari T. (2019) Genetic and Cell Biology Methods to Study ESCRTs in Drosophila melanogaster. Methods Mol Biol. 1998:13-29. doi: 10.1007/978-1-4939-9492-2_2.

Mastrodonato V, Morelli E, Vaccari T. (2018) How to use a multipurpose SNARE: The emerging role of Snap29 in cellular health. Cell Stress 2(4):72-81. doi: 10.15698/cst2018.04.130.

Alfred V, Vaccari T. (2018)  Mechanisms of Non-canonical Signaling in Health and Disease: Diversity to Take Therapy up a Notch? Adv Exp Med Biol. 1066:187-204. doi: 10.1007/978-3-319-89512-3_9.

Horner D, Pasini ME, Beltrame M, Mastrodonato V, Morelli E,  Vaccari T. (2017). ESCRT genes in developmental signaling. Seminars in Cell & Developmental Biology  pii: S1084-9521(16)30503-1. 

Tognon E, Vaccari T. (2014). Immunohistochemical tools and techniques to visualize Notch in Drosophila melanogaster. Methods Mol Biol. 2014;1187:63-78. doi: 10.1007/978-1-4939-1139-4_5.

Rusten TE, Vaccari T, Stenmark H (2012). Shaping Development with ESCRTs. Nature Cell Biology 22;14(1): 38-45. PDF-Nat Cell Biol-2012

Undergraduate courses thought by Thomas

  1. Biologia Generale e Ambientale con elementi di Istologia. Corso di laurea triennale in Scienze Naturali. 2018- ongoing (Fall Semester).
  2. Advanced Molecular and Cellular Biotechnology. Master of Science in Molecular Biotechnology and Bioinformatics – 2018- ongoing (Spring Semester)
  3. Cell Population Dynamics. Master of Science in Quantitative Biology – 2022- ongoing (Spring Semester)

    Graduate mentoring by Thomas

    Thomas is part of the faculty of the Molecular and Cellular Biology PhD program of the University of Milan